주식회사 노터스

비임상 CRO사업

Non-clinical CRO Business

바이오인프라구축사업

국내 비임상 CRO

유효성 부분 NO.1

신약 등 신규 개발 물질에 대한
동물 대상 비임상 실험 진행
수의학적 지식 및 영상 판독 능력을
기반으로 차별화 및 유효성에 집중

국내 비임상 CRO

유효성 부분 NO.1

신약 등 신규 개발 물질에 대한
동물 대상 비임상 실험 진행
수의학적 지식 및 영상 판독 능력을
기반으로
차별화 및 유효성에 집중

노터스의 유효성

암
( Cancer )

골질환
( Bone disease )

뇌신경질환
( Brain disease/Neuropathy )

내분비 및 대사질환
( Metabolic and endocrine disease )

안질환
( Eye disease )

간질환
( Liver )

순환계 질환
( Circulatory system )

in vitro and ex vivo

기타 질환
( Others )

분류	세부항목	세포주
Orthotopic	Bladder cancer	RT4
	Colon cancer	HCT116, HCT8
	Hepatic cancer	Hep3b
	Lung cancer	A549
	Ovary cancer	SK-OV-3
Syngeneic	Colon cancer	CT26, MC38
	Lung cancer	SCLC, LLC1
	Skin cancer	B16F10
Xenograft	Blood cancer	MM1S, MV-4-11
	Brain cancer	U87MG
	Breast cancer	SK-BR-3, MDA-MB-231, HCC-1937
	Colon cancer	Colo 205, HCT116, HT-29, RKO, HCT-15, LoVo, HCT-8, SW480, DLD-1, LS 174T, SW620
	Gastric cancer	NCI-N87, BT-474
	Hepatic cancer	Huh-7, HepG2, Hep3b
	Lung cancer	A549, NCI-H1975, NCI-H820, NCI-H1299, NCI-H1650, EBC-1, PC-9
	Pancreatic cancer	PANC-1
	Skin cancer	A375

분류	세부항목 / 시험모델
Osteoarthritis	Anterior cruciate ligament transection (ACLT), meniscectomy
	Collagenase-induced oseteoarthritis
	Monosodium Iodoacetate (MIA)-induced oseteoarthritis
Osteoporesis	Apolipoprotein E knockout (ApoE-/-) mice
Osteoporesis	Ovariectomy (OVX)-induced osteoporesis
Rheumarthritis	Collagen-induced arthritis (CIA)

분류	세부항목	시험모델
Brain infarction (stroke)	Middle cerebral artery occlusion (MCAO)	-
Brain infarction (stroke)	Thromboembolic infarction	-
Dementia	Alzheimer's disease	Amyloid-beta-induced neuronal dysfunction
	Alzheimer's disease	3xTg mice
	Parkinson's disease	APP/PS1 transgenic mice
		MPTP-induced parkinsonism
		Rotenone induced Parkinson's disease
Diabetic Neuropathy	Streptozocin (STZ)-induced diabetic neuropathy	-
Motor and Sensory Neuropathy	Charcot-Marie-Tooth (CMT)	-
Multiple Sclerosis (MS)	Experimental autoimmune encephalomyelitis (EAE)	-

분류	세부항목 / 시험모델
Climacterium	Ovariectomy (OVX)-induced climacterium
Diabetes	db/db mice (type 2 DM)
Diabetes	STZ-induced diabetes (type 1 DM)
Hyperlipidemia	High-fat / high-cholesterol diet-induced hyperlipidemia
Obesity	Diet-induced Obesity (DIO)

분류	세부항목	시험모델
Age-related macular degeneration (AMD)	Dry AMD	Sodium iodate (SI)-induced AMD
Age-related macular degeneration (AMD)	Wet AMD	Laser-induced Choroidal Neovascularization (CNV)
Corneal wound	Alkali burn	-
Corneal wound	Keratectomy	-
Diabetic retinopathy	STZ-induced diabetic retinopathy	-
Dry eye	Benzalkonium-induced dry eye	-
Glaucoma	Dexamethason-induced glaucoma	-
Glaucoma	Laser photoablation of trabecular meshwork	-

분류	세부항목 / 시험모델
Alcoholic liver disease	Chronic alcohol feeding
Liver Cirrhosis	Bild duct ligation
Liver Fibrosis	Dimethylnitrosamine-induced liver fibrosis
Liver Fibrosis	Carbon tetrachloride (CCl4)-induced liver fibrosis
Non-alcoholic fatty liver disease (NAFLD)	Methionin and choline deficient (MCD)-diet-induced NAFLD

분류	세부항목 / 시험모델
Carrageenan-induced paw edema	-
Hemophilia	Hemophilia A
Hemophilia	Hemophilia B
Hemorrhage	Liver laceration / transection
Hemorrhage	Spleen laceration / transection
Neutropenia	Cyclophosphamide (CPA)-induced neutropenia
Varicose vein	-

분류	세부항목	시험모델
Analysis	Antioxidant	DPPH, ABTS, SOD, OARC, Total polyphenol measure
	Cell biology	FACs analysis, Primary Cell culture, Cell differentiation test
	Immunology	Neutralizaing antibody assay, Total antibody assay, Immune cell Functional study (FACs), ELISPOT, ELISA
	Microbiology	MIC, MBC, MFC, Disk diffusion, Microbe inoculation
	Molecular biology	PCR, Real time RT-PCR, Western blotting, mouse genotyping
	Toxicology	MTT assay
	Virus	Virus culture, TCID, Plaque assay, Virus inactivation test
Experimental model	Experiment of Cell biology	Anti-obesity model, Cell toxicity model, Cell signaling pathway model
	Experiment of Disease and immunology	OA model, NASH model, Atopy model, psoriasis model, in vitro skin damage model by UV, anti-inflammation model
	Experiment of Microbiology	Anti-microbe effect model
	Experiment of Oncology	Tumor cell signaling pathway, Infilitrated leukocyte analysis model

분류	세부항목	시험모델
Cardiovascular system	Hypertension	SHR
	Hypertension	Monocrotaline-induced pulmonary hypertension
	Atrial fibrillation	Rapid atrial stimulation
	Atherosclerosis	Apolipoprotein E knockout (ApoE-/-) mice
	Critical limb ischemia (CLI)	-
Dentistry	Periodontitis	-
Gastro-Intestinal	Constipation	Morphine-induced constipation
	Esophageal stricture	Radio frequency ablation (RFA)-induced esophageal stricture
	Intestinal adhesions	-
	Inflammatory bowel disease (IBD), colitis	2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis
		Dextran sulfate sodium (DSS)-induced colitis
		Oxazolone-induced colitis
Hair	Alopecia	Dexamethasone-induced alopecia
		Dihydrotestosterone (DHT)-induced androgenetic alopecia
		Stress-induced alopecia
	Hair growth	-
Kidney	Acute renal failure	Cisplatin-induced acute renal failure
	Chronic renal failure	5/6 nephrectomy-induced chronic renal failure
	Renal fibrosis	Unilateral ureteral obstruction (UUO)-induced renal fibrosis
Pain	Chronic constriction injury (CCI)	-
	Diabetic Neuropathy	-
	PBQ-induced writhing test	-
Respiratory	Cough	Citric acid-induced cough
Respiratory	Organ bath	Bronchial smooth muscle and epithelium-dependent relaxation response
Skin	Atopic Dermatitis	Biostir-AD-induced atopic dermatitis in NC/Nga mice
	Burn Wound	-
	Wound	-

우수한 R&D 역량

국내 최대 동물병원과 연계된 CRO 기관으로 국내 최고의 전문인력과 시설 보유

경쟁사가 수행하기 어려운
고난이도 유효성 시험 가능
(수의사급 전문인력 활용)

수행시험결과의 Visual화로 결과의
정확성 및 신뢰성 확립
(MRI, CT 등 고스팩 장비의 활용)