신약 등 신규 개발 물질에 대한 비임상 CRO사업
비임상 CRO사업
Non-clinical CRO Business
국내 비임상 CRO
유효성 부분 NO.1
신약 등 신규 개발 물질에 대한
동물 대상 비임상 실험 진행
수의학적 지식 및 영상 판독 능력을
기반으로 차별화 및 유효성에 집중
비즈니스 이미지
국내 비임상 CRO
유효성 부분 NO.1
신약 등 신규 개발 물질에 대한
동물 대상 비임상 실험 진행
수의학적 지식 및 영상 판독 능력을
차별화 및 유효성에 집중
비즈니스 이미지
연구 사진
노터스의 유효성

( Cancer )
( Bone disease )
( Brain disease/Neuropathy )
내분비 및 대사질환
( Metabolic and endocrine disease )
( Eye disease )
( Liver )
순환계 질환
( Circulatory system )
in vitro and ex vivo
기타 질환
( Others )
분류 세부항목 세포주
Orthotopic Bladder cancer RT4
Colon cancer HCT116, HCT8
Hepatic cancer Hep3b
Lung cancer A549
Ovary cancer SK-OV-3
Syngeneic Colon cancer CT26, MC38
Lung cancer SCLC, LLC1
Skin cancer B16F10
Xenograft Blood cancer MM1S, MV-4-11
Brain cancer U87MG
Breast cancer SK-BR-3, MDA-MB-231, HCC-1937
Colon cancer Colo 205, HCT116, HT-29, RKO, HCT-15, LoVo, HCT-8, SW480, DLD-1, LS 174T, SW620
Gastric cancer NCI-N87, BT-474
Hepatic cancer Huh-7, HepG2, Hep3b
Lung cancer A549, NCI-H1975, NCI-H820, NCI-H1299, NCI-H1650, EBC-1, PC-9
Pancreatic cancer PANC-1
Skin cancer A375
분류 세부항목 / 시험모델
Osteoarthritis Anterior cruciate ligament transection (ACLT), meniscectomy
Collagenase-induced oseteoarthritis
Monosodium Iodoacetate (MIA)-induced oseteoarthritis
Osteoporesis Apolipoprotein E knockout (ApoE-/-) mice
Ovariectomy (OVX)-induced osteoporesis
Rheumarthritis Collagen-induced arthritis (CIA)
분류 세부항목 시험모델
Brain infarction (stroke) Middle cerebral artery occlusion (MCAO) -
Thromboembolic infarction -
Dementia Alzheimer's disease Amyloid-beta-induced neuronal dysfunction
3xTg mice
Parkinson's disease APP/PS1 transgenic mice
MPTP-induced parkinsonism
Rotenone induced Parkinson's disease
Diabetic Neuropathy Streptozocin (STZ)-induced diabetic neuropathy -
Motor and Sensory Neuropathy Charcot-Marie-Tooth (CMT) -
Multiple Sclerosis (MS) Experimental autoimmune encephalomyelitis (EAE) -
분류 세부항목 / 시험모델
Climacterium Ovariectomy (OVX)-induced climacterium
Diabetes db/db mice (type 2 DM)
STZ-induced diabetes (type 1 DM)
Hyperlipidemia High-fat / high-cholesterol diet-induced hyperlipidemia
Obesity Diet-induced Obesity (DIO)
분류 세부항목 시험모델
Age-related macular degeneration (AMD) Dry AMD Sodium iodate (SI)-induced AMD
Wet AMD Laser-induced Choroidal Neovascularization (CNV)
Corneal wound Alkali burn -
Keratectomy -
Diabetic retinopathy STZ-induced diabetic retinopathy -
Dry eye Benzalkonium-induced dry eye -
Glaucoma Dexamethason-induced glaucoma -
Laser photoablation of trabecular meshwork -
분류 세부항목 / 시험모델
Alcoholic liver disease Chronic alcohol feeding
Liver Cirrhosis Bild duct ligation
Liver Fibrosis Dimethylnitrosamine-induced liver fibrosis
Carbon tetrachloride (CCl4)-induced liver fibrosis
Non-alcoholic fatty liver disease (NAFLD) Methionin and choline deficient (MCD)-diet-induced NAFLD
분류 세부항목 / 시험모델
Carrageenan-induced paw edema -
Hemophilia Hemophilia A
Hemophilia B
Hemorrhage Liver laceration / transection
Spleen laceration / transection
Neutropenia Cyclophosphamide (CPA)-induced neutropenia
Varicose vein -
분류 세부항목 시험모델
Analysis Antioxidant DPPH, ABTS, SOD, OARC, Total polyphenol measure
Cell biology FACs analysis, Primary Cell culture, Cell differentiation test
Immunology Neutralizaing antibody assay, Total antibody assay, Immune cell Functional study (FACs), ELISPOT, ELISA
Microbiology MIC, MBC, MFC, Disk diffusion, Microbe inoculation
Molecular biology PCR, Real time RT-PCR, Western blotting, mouse genotyping
Toxicology MTT assay
Virus Virus culture, TCID, Plaque assay, Virus inactivation test
Experimental model Experiment of Cell biology Anti-obesity model, Cell toxicity model, Cell signaling pathway model
Experiment of Disease and immunology OA model, NASH model, Atopy model, psoriasis model, in vitro skin damage model by UV, anti-inflammation model
Experiment of Microbiology Anti-microbe effect model
Experiment of Oncology Tumor cell signaling pathway, Infilitrated leukocyte analysis model
분류 세부항목 시험모델
Cardiovascular system Hypertension SHR
Monocrotaline-induced pulmonary hypertension
Atrial fibrillation Rapid atrial stimulation
Atherosclerosis Apolipoprotein E knockout (ApoE-/-) mice
Critical limb ischemia (CLI) -
Dentistry Periodontitis -
Gastro-Intestinal Constipation Morphine-induced constipation
Esophageal stricture Radio frequency ablation (RFA)-induced esophageal stricture
Intestinal adhesions -
Inflammatory bowel disease (IBD), colitis 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis
Dextran sulfate sodium (DSS)-induced colitis
Oxazolone-induced colitis
Hair Alopecia Dexamethasone-induced alopecia
Dihydrotestosterone (DHT)-induced androgenetic alopecia
Stress-induced alopecia
Hair growth -
Kidney Acute renal failure Cisplatin-induced acute renal failure
Chronic renal failure 5/6 nephrectomy-induced chronic renal failure
Renal fibrosis Unilateral ureteral obstruction (UUO)-induced renal fibrosis
Pain Chronic constriction injury (CCI) -
Diabetic Neuropathy -
PBQ-induced writhing test -
Respiratory Cough Citric acid-induced cough
Organ bath Bronchial smooth muscle and epithelium-dependent relaxation response
Skin Atopic Dermatitis Biostir-AD-induced atopic dermatitis in NC/Nga mice
Burn Wound -
Wound -
우수한 R&D 역량
국내 최대 동물병원과 연계된 CRO 기관으로 국내 최고의 전문인력과 시설 보유
경쟁사가 수행하기 어려운
고난이도 유효성 시험 가능
(수의사급 전문인력 활용)
수행시험결과의 Visual화로 결과의
정확성 및 신뢰성 확립
(MRI, CT 등 고스팩 장비의 활용)